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Insulin travel coolers review

10 Best Insulin Travel Coolers to Keep Insulin Cool in 2021

Insulin is a temperature-sensitive medicine that needs to be protected from heat at all times. As a general rule, you in-use open insulin pens or vials should not be exposed to temperatures over 25°C/77°F. And your stocks of unopened insulin should be kept at fridge temperature. 

I’m a Type 1 diabetic and I’ve been traveling all over the world with my insulin kit for more than 10 years now. I’ve tried many different insulin coolers over the years and I know how hard it is to find the best one. Actually, there’s no such thing as the “best insulin travel cooler”. Each one of us has different needs, and the most important thing is to find the insulin cooler that best suits your own needs. That’s why I’ve put together the buyer’s guide to insulin coolers at the end of the article. It will guide you through all the features to look at in order to make the smartest purchase decision according to what your personal needs are. 


Best Insulin Coolers - Top 10 Products in 2021

#1. All4Family 72 Hours Insulin Cooler with USB Charger and Biopack Gel - Powered

All4Family is, by far, the best and most practical powered insulin cooler I’ve used. It’s a new product recently launched by 4AllFamily company. What’s so great about it? It offers 3 different cooling methods in one product. By switching the lids, you can transform your insulin cooler from a simple Icegel pack container into a real usb-charged mini-fridge. 

Laboratory tests have shown it can keep your insulin at fridge temperature (2-8°C/35-46°F) for 50 hours and at maximum 26°C/78°F for 72 hours when outside temperature is 35°C/95°F. This is the highest efficiency on the market today. 

Moreover, it has a high capacity: it can hold up to 7 insulin pens, 8 Novolog Vials, or 42 Humulin vials.

Plus, it’s light, portable, and very easy to use. I’ve just received the product myself and I am testing it for a full review that I’ll publish in a few weeks. Meanwhile, check out their website, it gives you all the detailed information about it.

#2. FRIO Wallets Insulin Cooling Cases - No Icepack!

If you’ve never heard about the famous FRIO Insulin Cooling cases, it’s time you do! These cooling bags are specially designed to protect temperature-sensitive medicines like insulin against high heat. What I love so much about them is that you do not need ice-packs nor electricity! The FRIO Cooling cases employ a patented technology that uses water evaporation to keep your insulin below 25°C/77°F for up to 48hours at outside temperatures of 38°C/100°F.

How to use Frio Wallets: All you need to make FRIO wallets work is cold water, which you can find absolutely everywhere. They include an inner wallet and an outer cover.“Immerse the inner wallet containing the crystals in cold water and soak for 8-10 minutes. Towel dry  and leave the wallet to dry off for 5 minutes. This allows the crystals to absorb any excess water. When semi-dry to the touc, place at the activated wallet in it’s outer cover. Place medication inside”. That’s it! No battery, no charger, no ice packs, no freezer needed! And they’re reusable for infinite number of times.

They’re very light and extremely convenient to protect your in-use insulin pens and vials during hot summer days. Plus, FRIO offers a large choice of sizes and styles. 

If you want more details, I’ve written a full product review about the FRIO Wallets

#3. Vivicap Reusable Insulin Cooler Travel Case for Insulin Pens - New Product!

I’m really exited about this recently launched insulin cooling case concept! Vivicap Reusable insulin pen cooler is an innovative new product that has no competitor (yet!). You will need this insulin pen cooler to protect your in-use insulin pens from outside high temperature. This novel high-technology keeps insulin below 29°/84°F for a minimum of 12 hours whatever the outside temperature is. And it magically regains its capacity whenever the ambient temperature gets back below 26°C/79°F. It also insulate your insulin from the cold and prevents it from freezing in extreme cold temperature. 

It requires absolutely no maintenance, no electricity, no freezer, no nothing! So, how does it work then? It’s based on a high-tech insulation and heat absorbing material that prevents heat from rising on the inside. 

Vivicap is extremely easy to use: just replace your insulin pen’s existing cap with the  device. It’s good for years of repetitive use. It has an indicator button that shows you the temperature status so you can control it. Vivicap is officially FDA registered for the cooling of insulin. You can safely use it. 

This new jewel is the smallest insulin pen cooler you can get, very lightweight (2oz/60g only!). It fits in your purse and even in your pocket for most convenience. Be careful when buying to choose the right size that fits your insulin pen. You can select different ones for Flexpen, Flextouch, Kwikpen, Reffilable pens, and Solostar insulin pens. 

I’ve just received it myself for trial, so I will soon publish a full product review about it. Meanwhile, here’s a Diabetes Educator and Vivicap user’s opinion

#4. GetBacktoBasix Fridge-to-Go Insulin Travel Bag for Cooling Diabetic Medicines - Freezer Panels

An insulin cooling bag designed by a diabetic entrepreneur! He knows what he’s talking about. Fridge-to-Go is the name of the insulin cooling bag designed by Robin, the Type 1 Diabetic man behind GetBacktoBasix company. These FDA-approved cooling bags use patented freezer panels filled with salt water that keep the interior temperature cool no matter what the external temperature is. 

What I love about Fridge-to-Go is its interior organised design. It has several zipper compartments and elasticised straps for insulin pens and vials not to move. And the exterior zipper is lovable, you can have a small padlock if you desire extra security.

Robin has thought about kids too, offering a Kids Epipen Holder with identification window and kids-friendly design. 


#5. Aijun Mini-Fridge for Insulin and Temperature-sensitive Medicines - Powered

Aijun mini-fridge is a best seller in the temperature-sensitive medicine category. Specially designed for diabetes drugs to stay refrigerated at all times, it’s an actual mini-fridge and really works just like a real fridge would do. So you’re safe your insulin is constantly properly stored. It keeps your insulin safe between 2-8°C/35-46°F, and has an anti-freeze security function.

It works on a 1040mAh battery for a duration of 10 hours when fully charged. A battery indicator lets you know when you need to recharge, which is very handy. It comes with 3 different charging system: a USB port, a cigaret lighter adapter (so you can charge it in your car), as well as a regular house hold power charger.

Its LCD display shows the time and the refrigeration temperature in both °C and °F. It can hold up to 3 insulin pens and 4 insulin vials. Internal refrigeration space: 170mm*55mm*23mm. External dimensions: 187mm*80mm*68mm.

I have not tested Aijun mini-fridge myself, but many of my readers have reported it’s a great product!

#6. LifeinaBox Portable Insulin and Medication Intelligent Connected Fridge - New Product!

LifeinaBox Portable Medication Fridge is another new product that did not exist when I first published this article. It’s the world’s smallest intelligent mini-fridge. It keeps  insulin and other temperature-sensitive medications safe at fridge temperature (2-8°C/35-46°F) for up to 6 hours when working on battery, and 24/7 when on power. There’s the possibility to buy separate battery packs to take with you on longer off-the-grid trips. 

Lifeina is a connected travel fridge: get the app on your phone and it monitors the temperature and the battery level of your fridge. Plus, there’s an alarm that automatically warns you when battery level is getting lower than 20%.

It can hold up to 8 insulin pens, and numerous insulin vials. Includes both a universal 110-240V power cord and a 12V DC power adapter for your car. 

#7. DisonCare 36H Portable Diabetic Travel Cooler with Temperature Display & QR Medical Tag

DisonCare Portable Insulin Cooling Bottle has been among the best insulin coolers for years now. It still is today, and with an even wider catalog of products! This one is the 36Hours Medication Cooler with temperature display and QR Medical tag. It’s a new upgraded version of the one I used to recommend before. 

DisonCare Insulin coolers for travelling diabetics are made with stainless steel and keep the insulin at fridge temperature (2-8°C/35-46°F) for up to 36 hours even if ambient temperature is at 30°/86°F. It’s a bit less than its All4Family competitor which keeps insulin at fridge temperature for 50 hours, but it’s still more than most other ones. It works with natural bio gel freezing packs. It comes with a touch temperature display for better control and tranquility.

My favourite feature: its eye catching QR Medical Tag. Anyone who scans the QR code can view your reserved information. It’s definitely a good reassuring idea for traveling diabetics, as you never know what can happen. Plus, if you loose the cooler, chances are higher someone will contact you.

The only downside I’ve found to this cooler is its limited capacity: you can only put 2 insulin pens, 2 insulin vials, or 12 Humilin vials. It’s probably enough for most of us, but if you’re traveling long term and need to refrigerate a 6-months stock of insulin like I do, you’d rather get the Extra-Capacity DisonCare Insulin Cooler: it comes at a higher price, but can hold up to 6 insulin pens, 8 insulin vials, or 42 Humilin vials, and its cooling performance is 45 hours! Check out all of DisonCare Insulin Coolers in their catalog here. The full diabetes kits are smart choices too. 

One last (great) thing about DisconCare: it has a 30-days money back policy, and offers a year warranty on its products. 

#8. Cooluli Mini-fridge Electric Cooler with On the Go USB Power Bank Option

Cooluli mini-fridge is not specially designed for medications, but it’s definitely one of my favourite insulin cooling solution. Many people use it for medications or for cosmetics. It’s a modern mini-fridge of 4-liters capacity with AC + DC + USB adapter so you can use it absolutely everywhere. It’s easy to transport thanks to its inset top handle. It’s without any doubt the largest capacity solution you can get. It works great and it’s actually one of the most purchased cooling system by my readers!

It’s ultra quite, 100% energy efficient, and has a cooling capacity of 40ºF-45ºF below ambient temperature. One thing to be aware of though: Cooluli mini-fridges do not work on battery. It needs power to function (USB, Car, or Household).

Outer dimensions: 7.6″x10.8″x10.25″. Inner dimension: 5.45″x8.12″x5.4″. Cooluli is expert in mini-fridges and offers a lot of different sizes, colors, and styles

#9. Apollo Walker Insulin Cooler Travel Case for Diabetic Medication with Ice Packs & Insulation Liner

Apollo Walker’s is Amazon’s best choice for the Insulin Cooler Travel case” category. It’s actually the most sold product and has great costumers reviews. It’s a very simple insulin cooling bag that includes 2 reusable ice packs and an interior insulation liner. 

It’s made with good quality durable material and a strong zipper closure. The outside is water resistant so it’s easy to clean. I especially like its interior organisation with elasticated product loops and pockets. It has a great capacity, and you can fit numerous insulin pens or insulin vials inside. It will keep your insulin cool and protected from outside high temperature from at least 12 hours.

Dimensions: 7.9” x 3.5”x 1.6”. Weight: 6.4 ounces. Exist in different colors: grey, purple, navy, blue. You get a 30 days money back policy and a year warranty. 

#10. MediCool Insulin Cooling Protector Case - Keeps at Fridge Temperature

MediCool is probably one of the oldest insulin cooling solution on the market. It still does a great job, and at a much lower price than most competitors. Only $24! It keeps insulin at fridge temperature for up to 16 hours. It comes with 2 freezer-safe cooler packs. Dimensions: 8″ x 4″ x 3″. It has inside pockets for syringes and alcohol swabs. Exist in black, blue, or red. 

Downside: this one is only for insulin vials (2 vials). You cannot fit insulin pens inside. But MediCool has another insulin cooling solution for insulin pens: the Poucho Wallets. They’re similar to FRIO’s cooling wallets, but I have not tested them myself. 

You get a year warranty on MediCool products.

How to Choose the Insulin Cooler that Best Suits your Needs

There are a lot of features to look at in order to make a smart choice when buying an insulin travel coolers. Temperature, duration, weight, powers, USB, capacity, price, etc… Finding the perfect cooler that fits all of your expectations is a tough task and you sometimes will have to make compromise. 

Here’s a little help to guide you through your purchase decision. I’ve listed all the important questions you need to ask yourself before buying your new cooler. For each of your answers, there’s a list of most suited insulin cooler suggestions. 

At what temperature do you need to transport your insulin?

To protect your in-use open insulin pens or vials from the daily ambient high temperature, you’ll need an insulin cooler that will keep your insulin below 25°C/77°F. It’s not necessary that your cooler goes as low as fridge temperature. You can use simpler and cheaper coolers such as Frio BagsViviCap deviceFridge-to-goApollo Walker case 

To transport stocks of insulin for more than a month, you’ll need a higher-performance cooler that guarantees your insulin is constantly kept at fridge temperature (2-8°C/35-46°F). As you know, insulin cannot be out of the fridge more than a month without risking going bad. You’ll need to use performant insulin coolers such as All4FamilyAijun mini-fridgeLifeinaBoxDisonCare BottleCooluli USB mini-fridgeMedicool protector

What duration do you need your insulin cooler to perform?

It’s not the same if you need your cooler for few hours day trips once in a while, or if you need it to transport your insulin cold for several days in a row. Before buying, read the cooler’s performance laboratory test results and check that it can keep your insulin safe for the time you need. Some can keep your insulin cool for as long as 72 hours! The highest-performance for autonomous (working on battery) insulin coolers at fridge temperature are: All4Family DisonCare Bottle.


Powered or a non-powered insulin cooler, USB, Car adapter?

Powered insulin coolers naturally have higher performances, but they’re less autonomous and require access to electricity at least to recharge the batteries. Most powered insulin coolers now come with USB chargers and Car adapter, which allows you to recharge the batteries from everywhere. Check at: All4Family– Aijun mini-fridge – LifeinaBox – DisonCare Bottle – Cooluli USB mini-fridge

Non-powered insulin coolers work with either freeze packs (you’ll need access to a freezer to activate it!), cold water, or even nothing! They give you more liberty than powered coolers, are much compact and light-weight, but are usually less performant. Check at: Frio Bags – ViviCap device – Fridge-to-go – Apollo Walker case – Medicool protector.

Capacity: how many insulin pens/vials do you need to keep cool?

If you need an insulin cooler to carry up to 3 insulin pens or vials, you’ll be well enough with low-capacity coolers such as: ViviCap device –Frio Bags – Fridge-to-go – Medicool protector – Aijun mini-fridge 

On the contrary, if you need your cooler to hold to more than 4 pens, check at high-capacity insulin coolers such as: All4Family – LifeinaBox – DisonCare Bottle  – Cooluli USB mini-fridge – Apollo Walker caseCooluli mini-fridge is the highest capacity you can find.

Weight / dimensions: are they important to you?

Depending on the kind of trip you’re planning, your priority might be to limit weight and dimensions as much as possible? In that case, choose a lighter option such as ViviCap device –Frio Bags – Fridge-to-go – Apollo Walker case.

How smart do you want your insulin cooler to be?

Some coolers are much more high-tech and connected than others. Do you want an alarm to warn you when you run out of battery? Would you like your cooler to display inside temperature? What about connecting it to your phone via an App? Would you be reassured with a security such as a QR Medical code? If you’re into technology and would appreciate that kind of options, check at the following coolers: All4Family – LifeinaBox – DisonCare Bottle 

TSA approved to fly with your diabetes supplies

If you’re going to fly with your diabetic supplies, you’ll need an insulin cooler that is approved by the TSA so you can carry it on board with you. All insulin coolers in this article are TSA-approved (expect Cooluli mini-fridge). If you’re flying with your diabetes supplies, don’t forget to download your Diabetes Travel Letter Template and ask your doctor to fill it in. You’ll need it to carry all of your supplies through airport security checks. 



Price matters for most of us. Some insulin coolers can be really expensive (LifeinaBox Smart mini-fridge for medicines costs more than $200!). If you can’t afford to pay much for your insulin cooler, there are options around $20 that work just great. The cheapest insulin coolers on this list are: Frio Bags – Fridge-to-go – Medicool protector – Apollo Walker case.

More about traveling with insulin

Here’s a list of articles that might interest you before traveling with insulin:

I hope this guide and product selection have been useful to you and you’ve found the insulin travel cooler of your dreams! If not, please do not hesitate to comment that post and ask your questions. I’ll be happy to help you with more information.

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About the author

Laura Pandolfi diabetes blogger

I’m Laura. Type 1 diabetic. Mother. Traveler. Writer. Researcher. I started this blog 5 years ago to investigate diabetes-related topics and share different views on the subject. I hope you find it useful!

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